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β-Cell Sensitivity to GLP-1 in Healthy Humans Is Variable and Proportional to Insulin Sensitivity

CONTEXT: Glucagon-like peptide-1 (GLP-1) is an insulinotropic factor made in the gastrointestinal tract that is essential for normal glucose tolerance. Infusion of GLP-1 increases insulin secretion in both diabetic and nondiabetic humans. However, the degree to which people vary in their β-cell sens...

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Podrobná bibliografie
Vydáno v:J Clin Endocrinol Metab
Hlavní autoři: Aulinger, Benedikt A., Vahl, Torsten P., Wilson-Pérez, Hilary E., Prigeon, Ron L., D'Alessio, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454808/
https://ncbi.nlm.nih.gov/pubmed/25825945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2014-4009
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