Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity

Cx3cr1, the receptor for the chemokine Cx3cl1 (fractalkine), has been implicated in the progression and severity of Alzheimer’s disease-like pathology in mice, but the underlying mechanisms remain unclear. A complicating factor is that Cx3cr1 has been demonstrated in both neurons and microglia. Here...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Dworzak, Jenny, Renvoisé, Benoît, Habchi, Johnny, Yates, Emma V., Combadière, Christophe, Knowles, Tuomas P., Dobson, Christopher M., Blackstone, Craig, Paulsen, Ole, Murphy, Philip M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454597/
https://ncbi.nlm.nih.gov/pubmed/26038823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127730
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