Somatic Copy Number Abnormalities and Mutations in PI3K/AKT/mTOR Pathway Have Prognostic Significance for Overall Survival in Platinum Treated Locally Advanced or Metastatic Urothelial Tumors

BACKGROUND: An integrative analysis was conducted to identify genomic alterations at a pathway level that could predict overall survival (OS) in patients with advanced urothelial carcinoma (UC) treated with platinum-based chemotherapy. PATIENTS AND METHODS: DNA and RNA were extracted from 103 formal...

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Veröffentlicht in:PLoS One
Hauptverfasser: Bellmunt, Joaquim, Werner, Lillian, Leow, Jeffrey J., Mullane, Stephanie A., Fay, André P., Riester, Markus, Van Hummelen, Paul, Taplin, Mary-Ellen, Choueiri, Toni K., Van Allen, Eliezer, Rosenberg, Jonathan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454515/
https://ncbi.nlm.nih.gov/pubmed/26039708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124711
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