The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress

The unfolded protein response (UPR) is activated in neurodegenerative tauopathies such as Alzheimer's disease (AD) in close connection with early stages of tau pathology. Metabolic disturbances are strongly associated with increased risk for AD and are a potent inducer of the UPR. Here, we demo...

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Publicat a:Cell Death Dis
Autors principals: van der Harg, J M, Nölle, A, Zwart, R, Boerema, A S, van Haastert, E S, Strijkstra, A M, Hoozemans, J JM, Scheper, W
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454326/
https://ncbi.nlm.nih.gov/pubmed/25165879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.354
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