The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress

The unfolded protein response (UPR) is activated in neurodegenerative tauopathies such as Alzheimer's disease (AD) in close connection with early stages of tau pathology. Metabolic disturbances are strongly associated with increased risk for AD and are a potent inducer of the UPR. Here, we demo...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: van der Harg, J M, Nölle, A, Zwart, R, Boerema, A S, van Haastert, E S, Strijkstra, A M, Hoozemans, J JM, Scheper, W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454326/
https://ncbi.nlm.nih.gov/pubmed/25165879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.354
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