Synthetic miR-34a mimics as a novel therapeutic agent for Multiple Myeloma: in vitro and in vivo evidence

PURPOSE: Deregulated expression of microRNAs (miRNAs) has been demonstrated in multiple myeloma (MM). A promising strategy to achieve a therapeutic effect by targeting the miRNA regulatory network is to enforce the expression of miRNAs that act as tumor suppressor genes, such as miR-34a. EXPERIMENTA...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Di Martino, Maria T., Leone, Emanuela, Amodio, Nicola, Foresta, Umberto, Lionetti, Marta, Pitari, Maria R., Gallo Cantafio, Maria E., Gullà, Annamaria, Conforti, Francesco, Morelli, Eugenio, Tomaino, Vera, Rossi, Marco, Negrini, Massimo, Ferrarini, Manlio, Caraglia, Michele, Shammas, Masood A., Munshi, Nikhil C., Anderson, Kenneth C., Neri, Antonino, Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453928/
https://ncbi.nlm.nih.gov/pubmed/23035210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1708
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