New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53

BACKGROUND: p53 is a transcription factor with tumour suppressor properties, which is able to induce mitochondrial apoptosis independently of its transcriptional activity. We recently synthesised two new compounds (ISA27 and SM13), which block p53-MDM2 interaction and induce apoptosis in p53 wild-ty...

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Podrobná bibliografie
Vydáno v:Br J Cancer
Hlavní autoři: Sorriento, D, Del Giudice, C, Bertamino, A, Ciccarelli, M, Gomez-Monterrey, I, Campiglia, P, Novellino, E, Illario, M, Trimarco, B, De Luca, N, Iaccarino, G
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453617/
https://ncbi.nlm.nih.gov/pubmed/25422906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.577
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