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Intrahost Dynamics of Antiviral Resistance in Influenza A Virus Reflect Complex Patterns of Segment Linkage, Reassortment, and Natural Selection

Resistance following antiviral therapy is commonly observed in human influenza viruses. Although this evolutionary process is initiated within individual hosts, little is known about the pattern, dynamics, and drivers of antiviral resistance at this scale, including the role played by reassortment....

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發表在:mBio
Main Authors: Rogers, Matthew B., Song, Timothy, Sebra, Robert, Greenbaum, Benjamin D., Hamelin, Marie-Eve, Fitch, Adam, Twaddle, Alan, Cui, Lijia, Holmes, Edward C., Boivin, Guy, Ghedin, Elodie
格式: Artigo
語言:Inglês
出版: American Society of Microbiology 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453542/
https://ncbi.nlm.nih.gov/pubmed/25852163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02464-14
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