Overexpression of SMYD2 contributes to malignant outcome in gastric cancer

BACKGROUND: SET and MYND domain-containing protein 2 (SMYD2) is a lysine methyltransferase for histone H3, p53 and Rb and inhibits their transactivation activities. In this study, we tested whether SMYD2 (1q42) acts as a cancer-promoting factor by being overexpressed in gastric cancer. METHODS: We a...

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Enregistré dans:
Détails bibliographiques
Publié dans:Br J Cancer
Auteurs principaux: Komatsu, S, Ichikawa, D, Hirajima, S, Nagata, H, Nishimura, Y, Kawaguchi, T, Miyamae, M, Okajima, W, Ohashi, T, Konishi, H, Shiozaki, A, Fujiwara, H, Okamoto, K, Tsuda, H, Imoto, I, Inazawa, J, Otsuji, E
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
Sujets:
Molecular Diagnostics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453442/
https://ncbi.nlm.nih.gov/pubmed/25321194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.543
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