Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma

BACKGROUND: PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) is a serine–threonine kinase and overexpressed in various types of cancer by inhibiting the transactivation activities of p53 and PTEN. We tested whether PBK/TOPK acts as a cancer-promoting gene through its activation/ove...

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Библиографические подробности
Опубликовано в: :Br J Cancer
Главные авторы: Ohashi, Takuma, Komatsu, Shuhei, Ichikawa, Daisuke, Miyamae, Mahito, Okajima, Wataru, Imamura, Taisuke, Kiuchi, Jun, Kosuga, Toshiyuki, Konishi, Hirotaka, Shiozaki, Atsushi, Fujiwara, Hitoshi, Okamoto, Kazuma, Tsuda, Hitoshi, Otsuji, Eigo
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
Предметы:
Molecular Diagnostics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5243986/
https://ncbi.nlm.nih.gov/pubmed/27898655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.394
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