Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition

BACKGROUND: The hypoxia-activated prodrug TH-302 is reduced at its nitroimidazole group and selectively under hypoxic conditions releases the DNA cross-linker bromo-isophosphoramide mustard (Br-IPM). Here, we have explored the effect of Chk1 inhibition on TH-302-mediated pharmacological activities....

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Meng, Fanying, Bhupathi, Deepthi, Sun, Jessica D, Liu, Qian, Ahluwalia, Dharmendra, Wang, Yan, Matteucci, Mark D, Hart, Charles P
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453293/
https://ncbi.nlm.nih.gov/pubmed/25994202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1387-6
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