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Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition
BACKGROUND: The hypoxia-activated prodrug TH-302 is reduced at its nitroimidazole group and selectively under hypoxic conditions releases the DNA cross-linker bromo-isophosphoramide mustard (Br-IPM). Here, we have explored the effect of Chk1 inhibition on TH-302-mediated pharmacological activities....
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| Publicado no: | BMC Cancer |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4453293/ https://ncbi.nlm.nih.gov/pubmed/25994202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1387-6 |
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