Combination treatment with hypoxia-activated prodrug evofosfamide (TH-302) and mTOR inhibitors results in enhanced antitumor efficacy in preclinical renal cell carcinoma models

Tumors often consist of hypoxic regions which are resistant to chemo- and radiotherapy. Evofosfamide (also known as TH-302), a 2-nitroimidazole triggered hypoxia-activated prodrug, preferentially releases the DNA cross-linker bromo-isophosphoramide mustard in hypoxic cells. The intracellular kinase...

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Bibliographic Details
Published in:Am J Cancer Res
Main Authors: Sun, Jessica D, Ahluwalia, Dharmendra, Liu, Qian, Li, Wenwu, Wang, Yan, Meng, Fanying, Bhupathi, Deepthi, Matteucci, Mark D, Hart, Charles P
Format: Artigo
Language:Inglês
Published: e-Century Publishing Corporation 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548326/
https://ncbi.nlm.nih.gov/pubmed/26328245
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