TIF1γ interferes with TGFβ1/SMAD4 signaling to promote poor outcome in operable breast cancer patients

BACKGROUND: The Transforming growth factor β (TGFβ) signaling has a paradoxical role in cancer development and outcome. Besides, the prognostic significance of the TGFβ1, SMAD4 in breast cancer patients is an area of many contradictions. The transcriptional intermediary factor 1γ (TIF1γ) is thought...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Kassem, Loay, Deygas, Mathieu, Fattet, Laurent, Lopez, Jonathan, Goulvent, Thibaut, Lavergne, Emilie, Chabaud, Sylvie, Carrabin, Nicolas, Chopin, Nicolas, Bachelot, Thomas, Gillet, Germain, Treilleux, Isabelle, Rimokh, Ruth
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453047/
https://ncbi.nlm.nih.gov/pubmed/26040677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1471-y
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