Formulation and In Vitro, In Vivo Evaluation of Effervescent Floating Sustained-Release Imatinib Mesylate Tablet

INTRODUCTION: Imatinib mesylate is an antineoplastic agent which has high absorption in the upper part of the gastrointestinal tract (GIT). Conventional imatinib mesylate (Gleevec) tablets produce rapid and relatively high peak blood levels and requires frequent administration to keep the plasma dru...

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Bibliographic Details
Published in:PLoS One
Main Authors: Kadivar, Ali, Kamalidehghan, Behnam, Javar, Hamid Akbari, Davoudi, Ehsan Taghizadeh, Zaharuddin, Nurul Dhania, Sabeti, Bahareh, Chung, Lip Yong, Noordin, Mohamed Ibrahim
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452730/
https://ncbi.nlm.nih.gov/pubmed/26035710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126874
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