Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [(18)F] FDG-PET imaging combined with proteomic approaches

BACKGROUND: Inhibition of mitogen-activated protein kinase (MEK, also known as MAPK2, MAPKK), a key molecule of the Ras/MAPK (mitogen-activated protein kinase) pathway, has shown promising effects on B-raf-mutated and some RAS (rat sarcoma)-activated tumors in clinical trials. The objective of this...

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Dettagli Bibliografici
Pubblicato in:EJNMMI Res
Autori principali: Tegnebratt, Tetyana, Ruge, Elisabeth, Bader, Sabine, Ishii, Nobuya, Aida, Satoshi, Yoshimura, Yasushi, Ooi, Chia-Huey, Lu, Li, Mitsios, Nicholas, Meresse, Valerie, Mulder, Jan, Pawlak, Michael, Venturi, Miro, Tessier, Jean, Stone-Elander, Sharon
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2014
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452660/
https://ncbi.nlm.nih.gov/pubmed/26116108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-014-0034-6
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