Strategy to develop a MAO-A-resistant 5-hydroxy-l-[β-(11)C]tryptophan isotopologue based on deuterium kinetic isotope effects

BACKGROUND: The serotonin precursor 5-hydroxy-l-[β-(11)C]tryptophan ([(11)C]HTP) is in clinical use for localization of neuroendocrine tumors and has been suggested as a proxy marker for pancreatic islet cells. However, degradation by monoamine oxidase-A (MAO-A) reduces retention and the contrast to...

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Bibliografische gegevens
Gepubliceerd in:EJNMMI Res
Hoofdauteurs: Eriksson, Jonas, Åberg, Ola, Selvaraju, Ram Kumar, Antoni, Gunnar, Johansson, Lars, Eriksson, Olof
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Berlin Heidelberg 2014
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452635/
https://ncbi.nlm.nih.gov/pubmed/26116123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-014-0062-2
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