Diversification of Paralogous α-Isopropylmalate Synthases by Modulation of Feedback Control and Hetero-Oligomerization in Saccharomyces cerevisiae

Production of α-isopropylmalate (α-IPM) is critical for leucine biosynthesis and for the global control of metabolism. The budding yeast Saccharomyces cerevisiae has two paralogous genes, LEU4 and LEU9, that encode α-IPM synthase (α-IPMS) isozymes. Little is known about the biochemical differences b...

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Vydáno v:Eukaryot Cell
Hlavní autoři: López, Geovani, Quezada, Héctor, Duhne, Mariana, González, James, Lezama, Mijail, El-Hafidi, Mohammed, Colón, Maritrini, Martínez de la Escalera, Ximena, Flores-Villegas, Mirelle Citlali, Scazzocchio, Claudio, DeLuna, Alexander, González, Alicia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452578/
https://ncbi.nlm.nih.gov/pubmed/25841022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00033-15
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