Phase I trial of arginine deprivation therapy with ADI-PEG 20 plus docetaxel in patients with advanced malignant solid tumors

PURPOSE: This phase I study examined the toxicity and tolerability, of pegylated arginine deiminase (ADI-PEG 20) in combination with docetaxel in patients with advanced solid malignancies. EXPERIMENTAL DESIGN: Eligible patients had histologically proven advanced solid malignancies, with any number o...

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Pubblicato in:Clin Cancer Res
Autori principali: Tomlinson, Benjamin K., Thomson, James A., Bomalaski, John S., Diaz, Monica, Akande, Taiwo, Mahaffey, Nichole, Li, Tianhong, Dutia, Mrinal P., Kelly, Karen, Gong, I-Yeh, Semrad, Thomas, Gandara, David R., Pan, Chong-Xian, Lara, Primo N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452427/
https://ncbi.nlm.nih.gov/pubmed/25739672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2610
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