Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM

Glioblastoma multiforme (GBM) remains a cancer with a poor prognosis and few effective therapeutic options. Successful medical management of GBM is limited by the restricted access of drugs to the central nervous system (CNS) caused by the blood brain barrier (BBB). We previously showed that a subse...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Przystal, Justyna Magdalena, Hajji, Nabil, Khozoie, Combiz, Renziehausen, Alexander, Zeng, Qingyu, Abaitua, Fernando, Hajitou, Amin, Suwan, Keittisak, Want, Elizabeth, Bomalaski, John, Szlosarek, Peter, O’Neill, Kevin, Crook, Tim, Syed, Nelofer
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294248/
https://ncbi.nlm.nih.gov/pubmed/30546006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1195-4
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