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Phosphorylation of the Gal4 DNA-Binding Domain Is Essential For Activator Mono-Ubiquitylation and Efficient Promoter Occupancy(¶)

Recent analysis of a Gal4 mutant (Gap71) carrying three point mutations (S22D, K23Q and K25F) in its DNA-binding domain (DBD), has demonstrated that it cannot occupy GAL promoters efficiently in cells and that it is not mono-ubiquitylated, suggesting a functional link between this modification and s...

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Publicat a:Mol Biosyst
Autors principals: Ferdous, Anwarul, O’Neal, Melissa, Nalley, Kip, Sikder, Devanjan, Kodadek, Thomas, Johnston, Stephen Albert
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451857/
https://ncbi.nlm.nih.gov/pubmed/18931787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b809291e
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