USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymerase eta stability

DNA polymerase eta (Polη) plays unique and pivotal functions in several DNA damage-tolerance pathways. Steady-state level of this short-lived protein is tightly controlled by multiple mechanisms including proteolysis. Here, we have identified the deubiquitinating enzyme, ubiquitin-specific protease...

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Publicat a:Oncogene
Autors principals: Qian, Jiang, Pentz, Kyle, Zhu, Qianzheng, Wang, Qien, He, Jinshan, Srivastava, Amit K., Wani, Altaf A.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451444/
https://ncbi.nlm.nih.gov/pubmed/25435364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.394
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