Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways

Interstitial fluid flow in and around the tumor tissue is a physiologically relevant mechanical signal that regulates intracellular signaling pathways throughout the tumor. Yet, the effects of interstitial flow and associated fluid shear stress on the tumor cell function have been largely overlooked...

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Pubblicato in:Oncogene
Autori principali: Wang, P, Chen, S-H, Hung, W-C, Paul, C, Zhu, F, Guan, P-P, Huso, DL, Kontrogianni-Konstantopoulos, A, Konstantopoulos, K
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451443/
https://ncbi.nlm.nih.gov/pubmed/25435370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.397
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