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Fluid-induced, shear stress-regulated extracellular matrix and matrix metalloproteinase genes expression on human annulus fibrosus cells

BACKGROUND: Mechanical loading plays an important role in the regulation of extracellular matrix (ECM) homeostasis as well as pathogenesis of intervertebral disc (IVD) degeneration. The human annulus fibrosus (hAF) in the IVD is subjected to contact shear stress during body motion. However, the effe...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Chou, Po-Hsin, Wang, Shih-Tien, Yen, Meng-Hua, Liu, Chien-Lin, Chang, Ming-Chau, Lee, Oscar Kuang-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769486/
https://ncbi.nlm.nih.gov/pubmed/26921206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-016-0292-5
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