Fluid shear stress-induced osteoarthritis: roles of cyclooxygenase-2 and its metabolic products in inducing the expression of proinflammatory cytokines and matrix metalloproteinases

The mechanical overloading of cartilage is involved in the pathophysiology of osteoarthritis (OA) by both biochemical and mechanical pathways. The application of fluid shear stress to chondrocytes recapitulates the earmarks of OA, as evidenced by the release of proinflammatory cytokines (PICs), matr...

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Detalhes bibliográficos
Main Authors: Wang, Pu, Guan, Pei-Pei, Guo, Chuang, Zhu, Fei, Konstantopoulos, Konstantinos, Wang, Zhan-You
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834778/
https://ncbi.nlm.nih.gov/pubmed/23964078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-234542
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