The Role of Cyclooxygenase-2, Interleukin-1β and Fibroblast Growth Factor-2 in the Activation of Matrix Metalloproteinase-1 in Sheared-Chondrocytes and Articular Cartilage

MMP-1 expression is detected in fluid shear stress (20 dyn/cm(2))-activated and osteoarthritic human chondrocytes, however, the precise mechanisms underlying shear-induced MMP-1 synthesis remain unknown. Using primary chondrocytes and T/C-28a2 chondrocytic cells as model systems, we report that prol...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Guan, Pei-Pei, Guo, Jing-Wen, Yu, Xin, Wang, Yue, Wang, Tao, Konstantopoulos, Konstantinos, Wang, Zhan-You, Wang, Pu
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438667/
https://ncbi.nlm.nih.gov/pubmed/25992485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10412
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk