The Role of Cyclooxygenase-2, Interleukin-1β and Fibroblast Growth Factor-2 in the Activation of Matrix Metalloproteinase-1 in Sheared-Chondrocytes and Articular Cartilage

MMP-1 expression is detected in fluid shear stress (20 dyn/cm(2))-activated and osteoarthritic human chondrocytes, however, the precise mechanisms underlying shear-induced MMP-1 synthesis remain unknown. Using primary chondrocytes and T/C-28a2 chondrocytic cells as model systems, we report that prol...

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Udgivet i:Sci Rep
Main Authors: Guan, Pei-Pei, Guo, Jing-Wen, Yu, Xin, Wang, Yue, Wang, Tao, Konstantopoulos, Konstantinos, Wang, Zhan-You, Wang, Pu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438667/
https://ncbi.nlm.nih.gov/pubmed/25992485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10412
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