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Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β
Gain-of-function mutations that activate the innate immune system can cause systemic autoinflammatory diseases associated with increased IL-1β production. This cytokine is activated identically to IL-18 by an intracellular protein complex known as the inflammasome; however, IL-18 has not yet been sp...
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| Wydane w: | J Exp Med |
|---|---|
| Główni autorzy: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
The Rockefeller University Press
2015
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4451132/ https://ncbi.nlm.nih.gov/pubmed/26008898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142384 |
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