Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β

Gain-of-function mutations that activate the innate immune system can cause systemic autoinflammatory diseases associated with increased IL-1β production. This cytokine is activated identically to IL-18 by an intracellular protein complex known as the inflammasome; however, IL-18 has not yet been sp...

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Udgivet i:J Exp Med
Main Authors: Kim, Man Lyang, Chae, Jae Jin, Park, Yong Hwan, De Nardo, Dominic, Stirzaker, Roslynn A., Ko, Hyun-Ja, Tye, Hazel, Cengia, Louise, DiRago, Ladina, Metcalf, Donald, Roberts, Andrew W., Kastner, Daniel L., Lew, Andrew M., Lyras, Dena, Kile, Benjamin T., Croker, Ben A., Masters, Seth L.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451132/
https://ncbi.nlm.nih.gov/pubmed/26008898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142384
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