Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance

Most studies on malaria-parasite digestion of hemoglobin (Hb) have been performed using P. falciparum maintained in mature erythrocytes, in vitro. In this study, we examine Plasmodium Hb degradation in vivo in mice, using the parasite P. berghei, and show that it is possible to create mutant parasit...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Lin, Jing-wen, Spaccapelo, Roberta, Schwarzer, Evelin, Sajid, Mohammed, Annoura, Takeshi, Deroost, Katrien, Ravelli, Raimond B.G., Aime, Elena, Capuccini, Barbara, Mommaas-Kienhuis, Anna M., O’Toole, Tom, Prins, Frans, Franke-Fayard, Blandine M.D., Ramesar, Jai, Chevalley-Maurel, Séverine, Kroeze, Hans, Koster, Abraham J., Tanke, Hans J., Crisanti, Andrea, Langhorne, Jean, Arese, Paolo, Van den Steen, Philippe E., Janse, Chris J., Khan, Shahid M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451122/
https://ncbi.nlm.nih.gov/pubmed/25941254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141731
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