Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance

Most studies on malaria-parasite digestion of hemoglobin (Hb) have been performed using P. falciparum maintained in mature erythrocytes, in vitro. In this study, we examine Plasmodium Hb degradation in vivo in mice, using the parasite P. berghei, and show that it is possible to create mutant parasit...

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書誌詳細
出版年:J Exp Med
主要な著者: Lin, Jing-wen, Spaccapelo, Roberta, Schwarzer, Evelin, Sajid, Mohammed, Annoura, Takeshi, Deroost, Katrien, Ravelli, Raimond B.G., Aime, Elena, Capuccini, Barbara, Mommaas-Kienhuis, Anna M., O’Toole, Tom, Prins, Frans, Franke-Fayard, Blandine M.D., Ramesar, Jai, Chevalley-Maurel, Séverine, Kroeze, Hans, Koster, Abraham J., Tanke, Hans J., Crisanti, Andrea, Langhorne, Jean, Arese, Paolo, Van den Steen, Philippe E., Janse, Chris J., Khan, Shahid M.
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2015
主題:
Brief Definitive Report
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451122/
https://ncbi.nlm.nih.gov/pubmed/25941254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141731
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