MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism

The MYC oncogene is frequently mutated and overexpressed in human renal cell carcinoma (RCC). However, there have been no studies on the causative role of MYC or any other oncogene in the initiation or maintenance of kidney tumorigenesis. Here, we show through a conditional transgenic mouse model th...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Shroff, Emelyn H., Eberlin, Livia S., Dang, Vanessa M., Gouw, Arvin M., Gabay, Meital, Adam, Stacey J., Bellovin, David I., Tran, Phuoc T., Philbrick, William M., Garcia-Ocana, Adolfo, Casey, Stephanie C., Li, Yulin, Dang, Chi V., Zare, Richard N., Felsher, Dean W.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
Physical Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450371/
https://ncbi.nlm.nih.gov/pubmed/25964345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507228112
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