Inactivation of a Gαs-PKA tumor suppressor pathway in skin stem cells initiates basal-cell carcinogenesis

Genomic alterations in GNAS, the gene coding for the Gαs heterotrimeric G-protein, are associated with a large number human of diseases. Here, we explored the role of Gαs on stem cell fate decisions by using the mouse epidermis as a model system. Conditional epidermal deletion of Gnas or repression...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Iglesias-Bartolome, Ramiro, Torres, Daniela, Marone, Romina, Feng, Xiaodong, Martin, Daniel, Simaan, May, Chen, Min, Weinstein, Lee S., Taylor, Susan S., Molinolo, Alfredo A., Gutkind, J. Silvio
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449815/
https://ncbi.nlm.nih.gov/pubmed/25961504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3164
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