Increased sensitivity of HPV-positive head and neck cancer cell lines to x-irradiation ± Cisplatin due to decreased expression of E6 and E7 oncoproteins and enhanced apoptosis

Squamous cell carcinoma of the head and neck region (HNSCC), which is related to an infection with human papilloma virus (HPV), responds better to simultaneous radio-chemotherapy with Cisplatin based regimens than HPV-negative tumors. The underlying molecular mechanisms for this clinical observation...

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Veröffentlicht in:Am J Cancer Res
Hauptverfasser: Ziemann, Frank, Arenz, Andrea, Preising, Stefanie, Wittekindt, Claus, Klussmann, Jens P, Engenhart-Cabillic, Rita, Wittig, Andrea
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449432/
https://ncbi.nlm.nih.gov/pubmed/26045983
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