Baseline Goblet Cell Mucin Secretion in the Airways Exceeds Stimulated Secretion over Extended Time Periods, and Is Sensitive to Shear Stress and Intracellular Mucin Stores

Airway mucin secretion studies have focused on goblet cell responses to exogenous agonists almost to the exclusion of baseline mucin secretion (BLMS). In human bronchial epithelial cell cultures (HBECCs), maximal agonist-stimulated secretion exceeds baseline by ~3-fold as measured over hour-long per...

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Vydáno v:PLoS One
Hlavní autoři: Zhu, Yunxiang, Abdullah, Lubna H., Doyle, Sean P., Nguyen, Kristine, Ribeiro, Carla M. P., Vasquez, Paula A., Forest, M. Gregory, Lethem, Michael I., Dickey, Burton F., Davis, C. William
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449158/
https://ncbi.nlm.nih.gov/pubmed/26024524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127267
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