Baseline Goblet Cell Mucin Secretion in the Airways Exceeds Stimulated Secretion over Extended Time Periods, and Is Sensitive to Shear Stress and Intracellular Mucin Stores

Airway mucin secretion studies have focused on goblet cell responses to exogenous agonists almost to the exclusion of baseline mucin secretion (BLMS). In human bronchial epithelial cell cultures (HBECCs), maximal agonist-stimulated secretion exceeds baseline by ~3-fold as measured over hour-long per...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhu, Yunxiang, Abdullah, Lubna H., Doyle, Sean P., Nguyen, Kristine, Ribeiro, Carla M. P., Vasquez, Paula A., Forest, M. Gregory, Lethem, Michael I., Dickey, Burton F., Davis, C. William
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449158/
https://ncbi.nlm.nih.gov/pubmed/26024524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127267
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