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Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis
The small GTPase Cdc42 is a key regulator of polarity, but little is known in mammals about its spatial regulation and the relevance of spatial Cdc42 pools for polarity. Here, we report the identification of a GM130-RasGRF complex as a regulator of Cdc42 at the Golgi. Silencing GM130 results in RasG...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4449154/ https://ncbi.nlm.nih.gov/pubmed/25208761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5839 |
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