BRCA1 Is Required for Common-Fragile-Site Stability via Its G(2)/M Checkpoint Function

Common fragile sites are loci that form chromosome gaps or breaks when DNA synthesis is partially inhibited. Fragile sites are prone to deletions, translocations, and other rearrangements that can cause the inactivation of associated tumor suppressor genes in cancer cells. It was previously shown th...

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Detalhes bibliográficos
Main Authors: Arlt, Martin F., Xu, Bo, Durkin, Sandra G., Casper, Anne M., Kastan, Michael B., Glover, Thomas W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC444841/
https://ncbi.nlm.nih.gov/pubmed/15254237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.15.6701-6709.2004
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