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BRCA1 Is Required for Common-Fragile-Site Stability via Its G(2)/M Checkpoint Function
Common fragile sites are loci that form chromosome gaps or breaks when DNA synthesis is partially inhibited. Fragile sites are prone to deletions, translocations, and other rearrangements that can cause the inactivation of associated tumor suppressor genes in cancer cells. It was previously shown th...
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| Main Authors: | , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
American Society for Microbiology
2004
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC444841/ https://ncbi.nlm.nih.gov/pubmed/15254237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.15.6701-6709.2004 |
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