Two Molecularly Distinct G(2)/M Checkpoints Are Induced by Ionizing Irradiation

Cell cycle checkpoints are among the multiple mechanisms that eukaryotic cells possess to maintain genomic integrity and minimize tumorigenesis. Ionizing irradiation (IR) induces measurable arrests in the G(1), S, and G(2) phases of the mammalian cell cycle, and the ATM (ataxia telangiectasia mutate...

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Detalhes bibliográficos
Main Authors: Xu, Bo, Kim, Seong-Tae, Lim, Dae-Sik, Kastan, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC134638/
https://ncbi.nlm.nih.gov/pubmed/11809797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.4.1049-1059.2002
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