The CXCL12/CXCR4 Axis Plays a Critical Role in Coronary Artery Development

The chemokine CXCL12 and its receptor CXCR4 have many functions during embryonic and post-natal life. We used murine models to investigate the role of CXCL12/CXCR4 signaling in cardiac development and found that embryonic Cxcl12-null hearts lacked intra-ventricular coronary arteries (CAs) and exhibi...

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Publicado en:Dev Cell
Autores principales: Ivins, Sarah, Chappell, Joel, Vernay, Bertrand, Suntharalingham, Jenifer, Martineau, Alexandrine, Mohun, Timothy J., Scambler, Peter J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4448146/
https://ncbi.nlm.nih.gov/pubmed/26017770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.03.026
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