EPHB4 Protein Expression in Vascular Smooth Muscle Cells Regulates Their Contractility, and EPHB4 Deletion Leads to Hypotension in Mice

EPH kinases are the largest family of receptor tyrosine kinases, and their ligands, ephrins (EFNs), are also cell surface molecules. This work presents evidence that EPHB4 on vascular smooth muscle cells (VSMCs) is involved in blood pressure regulation. We generated gene KO mice with smooth muscle c...

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Vydáno v:J Biol Chem
Hlavní autoři: Wang, Yujia, Thorin, Eric, Luo, Hongyu, Tremblay, Johanne, Lavoie, Julie L., Wu, Zenghui, Peng, Junzheng, Qi, Shijie, Wu, Jiangping
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447992/
https://ncbi.nlm.nih.gov/pubmed/25903126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.621615
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