Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia

The ATP-binding cassette (ABC) transporter cystic fibrosis transmembrane conductance regulator (CFTR) and two other non-membrane-bound ABC proteins, Rad50 and a structural maintenance of chromosome (SMC) protein, exhibit adenylate kinase activity in the presence of physiologic concentrations of ATP...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Dong, Qian, Ernst, Sarah E., Ostedgaard, Lynda S., Shah, Viral S., Ver Heul, Amanda R., Welsh, Michael J., Randak, Christoph O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447984/
https://ncbi.nlm.nih.gov/pubmed/25887396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611616
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