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ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity
ADP interacts with the nucleotide-binding domains (NBDs) of the cystic fibrosis transmembrane conductance regulator (CFTR) to inhibit its Cl(-) channel activity. Because CFTR NBD2 has reversible adenylate kinase activity (ATP + AMP ⇆ ADP + ADP) that gates the channel, we asked whether ADP might inhi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2005
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC548590/ https://ncbi.nlm.nih.gov/pubmed/15684079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409787102 |
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