Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling

A single intrathecal dose of adenosine 2A receptor (A(2A)R) agonist was previously reported to produce a multi-week reversal of allodynia in a chronic constriction injury (CCI) model of neuropathic pain. We aimed to determine if this long-term reversal was induced by A(2A)R agonism versus more gener...

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Bibliographic Details
Published in:Brain Behav Immun
Main Authors: Loram, Lisa C, Taylor, Frederick R, Strand, Keith A, Harrison, Jacqueline A, RzasaLynn, Rachael, Sholar, Paige, Rieger, Jayson, Maier, Steven F, Watkins, Linda R
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447865/
https://ncbi.nlm.nih.gov/pubmed/23811314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2013.06.004
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