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APOEε2 is associated with milder clinical and pathological Alzheimer's disease

OBJECTIVE: The Alzheimer disease (AD) APOEε4 risk allele associates with an earlier age of onset and increased amyloid-β deposition, whereas the protective APOEε2 allele delays the onset and appears to prevent amyloid-β deposition. Yet the clinical and pathological effects of APOEε2 remain uncertain...

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Bibliographic Details
Published in:Ann Neurol
Main Authors: Serrano-Pozo, Alberto, Qian, Jing, Monsell, Sarah E., Betensky, Rebecca A., Hyman, Bradley T.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447539/
https://ncbi.nlm.nih.gov/pubmed/25623662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24369
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