Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis In Vivo

Recent work demonstrated that the Niemann-Pick C1 (NPC1) protein is an essential entry receptor for filoviruses. While previous studies focused on filovirus entry requirements of NPC1 in vitro, its roles in filovirus replication and pathogenesis in vivo remain unclear. Here, we evaluated the importa...

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Detalles Bibliográficos
Publicado en:mBio
Main Authors: Herbert, Andrew S., Davidson, Cristin, Kuehne, Ana I., Bakken, Russell, Braigen, Stephen Z., Gunn, Kathryn E., Whelan, Sean P., Brummelkamp, Thijn R., Twenhafel, Nancy A., Chandran, Kartik, Walkley, Steven U., Dye, John M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Microbiology 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447246/
https://ncbi.nlm.nih.gov/pubmed/26015498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00565-15
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