Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis In Vivo

Recent work demonstrated that the Niemann-Pick C1 (NPC1) protein is an essential entry receptor for filoviruses. While previous studies focused on filovirus entry requirements of NPC1 in vitro, its roles in filovirus replication and pathogenesis in vivo remain unclear. Here, we evaluated the importa...

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Bibliografiske detaljer
Udgivet i:mBio
Main Authors: Herbert, Andrew S., Davidson, Cristin, Kuehne, Ana I., Bakken, Russell, Braigen, Stephen Z., Gunn, Kathryn E., Whelan, Sean P., Brummelkamp, Thijn R., Twenhafel, Nancy A., Chandran, Kartik, Walkley, Steven U., Dye, John M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Microbiology 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447246/
https://ncbi.nlm.nih.gov/pubmed/26015498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00565-15
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