Halofuginone inhibits the establishment and progression of melanoma bone metastases

Transforming growth factor (TGF-β) derived from bone fuels melanoma bone metastases by inducing tumor secretion of pro-metastatic factors that act on bone cells to change the skeletal microenvironment. Halofuginone is a plant alkaloid derivative that blocks TGF-β signaling with antiangiogenic and an...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Juárez, Patricia, Mohammad, Khalid S., Yin, Juan Juan, Fournier, Pierrick GJ., McKenna, Ryan C., Davis, Holly W., Peng, Xiang H., Niewolna, Maria, Javelaud, Delphine, Chirgwin, John M., Mauviel, Alain, Guise, Theresa A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447239/
https://ncbi.nlm.nih.gov/pubmed/23002206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1444
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