Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C

BACKGROUND: Prostate cancer is one of the most common malignancies in men. The mucin 1 (MUC1) heterodimeric oncoprotein is overexpressed in human prostate cancers with aggressive pathologic and clinical features, resulting in a poor outcome. However, the functional role for MUC1 C-terminal domain (M...

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Veröffentlicht in:J Exp Clin Cancer Res
Hauptverfasser: Li, Jing, Xiang, SongTao, Zhang, QiouHong, Wu, JingJing, Tang, Qing, Zhou, JianFu, Yang, LiJun, Chen, ZhiQiang, Hann, Swei Sunny
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446835/
https://ncbi.nlm.nih.gov/pubmed/25971429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-015-0168-z
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