Tackling the Cytotoxic Effect of a Marine Polycyclic Quinone-Type Metabolite: Halenaquinone Induces Molt 4 Cells Apoptosis via Oxidative Stress Combined with the Inhibition of HDAC and Topoisomerase Activities

A marine polycyclic quinone-type metabolite, halenaquinone (HQ), was found to inhibit the proliferation of Molt 4, K562, MDA-MB-231 and DLD-1 cancer cell lines, with IC(50) of 0.48, 0.18, 8.0 and 6.76 μg/mL, respectively. It exhibited the most potent activity against leukemia Molt 4 cells. Accumulat...

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Publicado no:Mar Drugs
Main Authors: Shih, Shou-Ping, Lee, Man-Gang, El-Shazly, Mohamed, Juan, Yung-Shun, Wen, Zhi-Hong, Du, Ying-Chi, Su, Jui-Hsin, Sung, Ping-Jyun, Chen, Yu-Cheng, Yang, Juan-Cheng, Wu, Yang-Chang, Lu, Mei-Chin
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446623/
https://ncbi.nlm.nih.gov/pubmed/26006712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md13053132
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